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牛彦

副教授

理学博士,副教授,硕士生导师

办公电话: +86-10-82805281 电子邮箱:?yanniu@bjmu.edu.cn

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学习经历

2015.9-2016.9 德国康斯坦茨大学化学生物学与药理学系??? 访问学者

2013.8-?今????? 北京大学药学院?? ag现场厅|官网?????副教授,硕士生导师;

2007.8-2013.7?北京大学药学院?? ag现场厅|官网??????讲师;

2002.9-2007.7?北京大学药学院?? 化学生物学专业???博士;

1998.9-2002.7?北京大学药学院?? ?药学专业???????本科。

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讲授课程

《药物化学》、《药物化学进展》、《计算机辅助药物设计》。

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研究方向与兴趣

1. ?药物先导化合物的发现和优化;

2. ?基于靶标结构的药物分子设计与化学合成;

3. ?活性小分子构效关系研究

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获得奖励

1. 2008年??药学院第八届青年教师教学演示竞赛??二等奖

2. 2009年??北京大学医学部????优秀教师奖

3. 2010年???北京大学优秀班主任??二等奖

4. 2010年???北京大学药学院????优秀共产党员

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代表性论文

Gang Yan, Lina Hao, Yan Niu*, Wenjie Huang, Wei Wang, Fengrong Xu, Lei Liang, Chao Wang, Hongwei Jin, Ping Xu*, 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies, European Journal of Medicinal Chemistry , 2017, 137: 462–475

Jing Sun, Yan Niu*, Chao Wang, Hao Zhang, Bingyu Xie, Fengrong Xu, Hongwei Jin, Yihong Peng, Lei Liang, Ping Xu*, Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents, Bioorganic & Medicinal Chemistry , 2016, 24: 3472–3482

Qi Sun, Bo Xu, Yan Niu*, Fengrong Xu, Lei Liang, Chao Wang, Jiapei Yu, Gang Yan, Wei Wang, Hongwei Jin*, Ping Xu*. Synthesis, Bioactivity, Docking and Molecular Dynamics Studies of Furan-Based Peptides as 20S Proteasome Inhibitors. ChemMedChem , 2015, 10, 498–510.

Peng Liu,?Yan Niu,* Chao Wang, Qi Sun, Yaya Zhai, Jiapei Yu,Jing Sun, Fengrong Xu, Gang Yan, Wenjie Huang, Lei Liang, Ping Xu*, 4-Oxo-1,4-dihydroquinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies,? European Journal of Medicinal Chemistry. ?2014, 79: 413- 421.

Chao Wang, Hao Zhang, Fengrong Xu,?Yan Niu*, Yun Wu, Xin Wang, Yihong Peng,Jing Sun, Lei Liang and Ping Xu* , Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents,? Molecules ,?2013, 18, 6057-6091.

Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun, Ping Xu*, Design, synthesis and in vitro biological evaluation of 3-styrylbenzimidamides as potential BACE1 inhibitors,? Letters in Drug Design & Discovery , 2013, 10?( 4 ): 297-302

Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun,?Ping Xu*, Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors,? Chem Biol Drug Des ,?2012,?80: 775–780

Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang?and Ping Xu*, The Discovery of Novel b-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies,? Chem Biol Drug Des ,?2012, 79:972-80

ag亚游app科技|首页 Dong Wang, Liguo Yang, Jingjing Su,?Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu,?Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline,? Biochemical and Biophysical Research Communications ,?2011, 410: 229–234

Yan Niu,?Yuehua Wang,?Xiaomin Zou,?Xiaoming Yang,?Chao Ma,?Yang Lü,?Bo Zhou,?Yue Yuan,?Guanhua Du and?Ping Xu*.?Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase.? European Journal of Medicinal Chemistry. ?2010, 45: 2089–2094

Bo Zhou,?Yan Niu, Xiao-Min Zou, Feng-Rong Xu, Yue Yuan, Chao Wang, Hai-Fei Gao, Peng Liu, Ping Xu*, Structure-based design of hexahydropyrimidin-5-ols as novel non-peptidic β-secretase inhibitors,? Journal of Chinese Pharmaceutical Sciences , 2010,?19?(5):?391-400.

Wen Si, Xuliang Zhang,?Yan Niu, Huiting Yu, Xiaoping Lei, Huanxin Chen, Xiaohua Cao, A novel derivative of xanomeline improves fear cognition in aged mice,? Neuroscience Letters , 2010, 473: 115–119

Yihui Cui, Dong Wang, Wen Si, Wen Lu,?Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao*, Enhancement of memory function in aged mice by a novel derivative of xanomeline,? Cell Research , 2008: 1-3

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中国专利

(1) 徐萍,彭宜红,王超,牛彦,张浩,许凤荣,具有MEK抑制功能的化合物及其制备方法与应用,2015.11.18-2035.11.19,中国,CN201210440137.X

(2) 徐萍,牛彦,高海飞,许凤荣,具有β-分泌酶抑制功能的化合物及其制备方法与应用,2013.4.3-2031.9.20,中国,CN201110279736.3

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